ZOLEDRONIC ACID

Brand Name & Strength

Zometa 4 mg/5 ml, 4 mg/100 ml

Reconstitution

Not required

Further Dilution

Dilute with 100 ml of diluent (for 4 mg/5 ml)[1,2]

Diluent

NS, D5 (calcium free infusion solution)

Administration & Infusion rate

IV infusion

Administer single infusion in no less than 15 min

Storage & Stability

RT

(<25 oC)

Fridge

(2-8 oC)

After Reconstitution

- -

After dilution

- 24 hr (from dilution until end of administration)

Remarks

Maintain adequate hydration prior to and following administration of Zoledronic Acid Refrigerated solutions must be allowed to reach room temperature before administration. Flush IV line with 10 ml NS following infusion. Infuse in a line separate from other medications.